The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition

Human patients carrying PAPP‐A2 inactivating mutations have low bone mineral density. The underlying mechanisms for this reduced calcification are poorly understood. Using a zebrafish model, we report that Papp-aa regulates bone calcification by promoting Ca(2+)-transporting epithelial cell (ionocyt...

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Detalles Bibliográficos
Autores principales: Liu, Chengdong, Li, Shuang, Noer, Pernille Rimmer, Kjaer-Sorensen, Kasper, Juhl, Anna Karina, Goldstein, Allison, Ke, Caihuan, Oxvig, Claus, Duan, Cunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185994/
https://www.ncbi.nlm.nih.gov/pubmed/32293560
http://dx.doi.org/10.7554/eLife.52322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185994/
https://www.ncbi.nlm.nih.gov/pubmed/32293560
http://dx.doi.org/10.7554/eLife.52322

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