Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

The cyclic GMP-AMP synthase (cGAS) is a widely used DNA sensor, which detects cytosolic DNA species without a preference of self or non-self microbial DNA in interphase to initiate innate immune response. How cGAS is regulated to avoid self-DNA sensing upon nuclear envelope breakdown (NEBD) during m...

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Detalles Bibliográficos
Autores principales: Zhong, Li, Hu, Ming-Ming, Bian, Li-Jun, Liu, Ying, Chen, Qiang, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186227/
https://www.ncbi.nlm.nih.gov/pubmed/32351706
http://dx.doi.org/10.1038/s41421-020-0162-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186227/
https://www.ncbi.nlm.nih.gov/pubmed/32351706
http://dx.doi.org/10.1038/s41421-020-0162-2

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