Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

ABSTRACT: Topoisomerase IIα (topo2α) is an essential nuclear enzyme involved in DNA replication, transcription, recombination, chromosome condensation, and highly expressed in many tumors. Thus, topo2α-targeting has become a very efficient and well-established anticancer strategy. Herein, we investi...

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Detalles Bibliográficos
Autores principales: Legina, Maria S., Nogueira, Juan J., Kandioller, Wolfgang, Jakupec, Michael A., González, Leticia, Keppler, Bernhard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186247/
https://www.ncbi.nlm.nih.gov/pubmed/32193613
http://dx.doi.org/10.1007/s00775-020-01775-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186247/
https://www.ncbi.nlm.nih.gov/pubmed/32193613
http://dx.doi.org/10.1007/s00775-020-01775-2

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