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Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

ABSTRACT: Topoisomerase IIα (topo2α) is an essential nuclear enzyme involved in DNA replication, transcription, recombination, chromosome condensation, and highly expressed in many tumors. Thus, topo2α-targeting has become a very efficient and well-established anticancer strategy. Herein, we investi...

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Detalles Bibliográficos
Autores principales:	Legina, Maria S., Nogueira, Juan J., Kandioller, Wolfgang, Jakupec, Michael A., González, Leticia, Keppler, Bernhard K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186247/ https://www.ncbi.nlm.nih.gov/pubmed/32193613 http://dx.doi.org/10.1007/s00775-020-01775-2

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