Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras–PDAC model

SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kra...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Wei, Dongping, Tan, Mingjia, Li, Haomin, Morgan, Meredith A., Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186265/
https://www.ncbi.nlm.nih.gov/pubmed/32339950
http://dx.doi.org/10.1016/j.neo.2020.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186265/
https://www.ncbi.nlm.nih.gov/pubmed/32339950
http://dx.doi.org/10.1016/j.neo.2020.03.002

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