Suppression of FVIII-Specific Memory B Cells by Chimeric BAR Receptor-Engineered Natural Regulatory T Cells

Anti-drug antibody formation poses tremendous obstacles for optimal treatment of hemophilia A (HA). In this study, we sought to utilize chimeric receptor-modified natural regulatory T cells (Tregs) to target FVIII-specific memory B cells, which are responsible for persistent anti-FVIII neutralizing...

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Detalles Bibliográficos
Autores principales: Pohl, Alessandra De Paula, Venkatesha, Shivaprasad H., Zhang, Ai-Hong, Scott, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186411/
https://www.ncbi.nlm.nih.gov/pubmed/32373126
http://dx.doi.org/10.3389/fimmu.2020.00693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186411/
https://www.ncbi.nlm.nih.gov/pubmed/32373126
http://dx.doi.org/10.3389/fimmu.2020.00693

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