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Cilostazol, a Phosphodiesterase 3 Inhibitor, Moderately Attenuates Behaviors Depending on Sex in the Ts65Dn Mouse Model of Down Syndrome

People with Down syndrome, which is a trisomy of chromosome 21, exhibit intellectual disability from infancy and neuropathology similar to Alzheimer’s disease, such as amyloid plaques, from an early age. Recently, we showed that cilostazol, a selective inhibitor of phosphodiesterase (PDE) 3, promote...

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Detalles Bibliográficos
Autores principales:	Tsuji, Masahiro, Ohshima, Makiko, Yamamoto, Yumi, Saito, Satoshi, Hattori, Yorito, Tanaka, Emi, Taguchi, Akihiko, Ihara, Masafumi, Ogawa, Yuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186592/ https://www.ncbi.nlm.nih.gov/pubmed/32372946 http://dx.doi.org/10.3389/fnagi.2020.00106

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