Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

Structure‐based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. Herein, we show that ligand screening can be performed in living human cells by “intracellular prot...

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Detalles Bibliográficos
Autores principales: Luchinat, Enrico, Barbieri, Letizia, Cremonini, Matteo, Nocentini, Alessio, Supuran, Claudiu T., Banci, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187179/
https://www.ncbi.nlm.nih.gov/pubmed/32022355
http://dx.doi.org/10.1002/anie.201913436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187179/
https://www.ncbi.nlm.nih.gov/pubmed/32022355
http://dx.doi.org/10.1002/anie.201913436

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