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Enantioselective Synthesis of a Tricyclic, sp(3)‐Rich Diazatetradecanedione: an Amino Acid‐Based Natural Product‐Like Scaffold

6‐, 7‐, and 8‐membered rings are assembled from a linear precursor by successive cyclisation reactions to construct a tricyclic diazatricyclo[6.5.1.0(4, 9)]‐tetradecanedione scaffold. Advanced building blocks based on d‐aspartic acid and l‐pyroglutamic acid were combined by a sp(3)−sp(2) Negishi cou...

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Detalles Bibliográficos
Autores principales: Bischoff, Matthias, Mayer, Peter, Meyners, Christian, Hausch, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187416/
https://www.ncbi.nlm.nih.gov/pubmed/31846111
http://dx.doi.org/10.1002/chem.201905144