Chimeric LuxR Transcription Factors Rewire Natural Product Regulation

LuxR‐type transcriptional activator proteins frequently regulate the expression of biosynthetic gene clusters (BGCs). With only a fraction of bacterial BGCs being expressed under standard culturing conditions, modulation of LuxRs would provide a powerful approach to activate silent clusters. We show...

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Detalles Bibliográficos
Autores principales: Mukherji, Ruchira, Zhang, Shuaibing, Chowdhury, Somak, Stallforth, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187462/
https://www.ncbi.nlm.nih.gov/pubmed/31943579
http://dx.doi.org/10.1002/anie.201914449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187462/
https://www.ncbi.nlm.nih.gov/pubmed/31943579
http://dx.doi.org/10.1002/anie.201914449

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