CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling

BACKGROUND: Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer type. CPI-613 (Devimistat), a novel lipoate analog inhibiting mitochondrial meta...

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Detalles Bibliográficos
Autores principales: Gao, Lixia, Xu, Zhigang, Huang, Zheng, Tang, Yan, Yang, Donglin, Huang, Jiuhong, He, Leilei, Liu, Manran, Chen, Zhongzhu, Teng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187515/
https://www.ncbi.nlm.nih.gov/pubmed/32345326
http://dx.doi.org/10.1186/s13046-020-01579-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187515/
https://www.ncbi.nlm.nih.gov/pubmed/32345326
http://dx.doi.org/10.1186/s13046-020-01579-x

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