Reduced neurosteroid potentiation of GABA(A) receptors in epilepsy and depolarized hippocampal neurons

OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ‐aminobutyric acid type‐A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is altered. We tested whether similar changes occur in...

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Detalles Bibliográficos
Autores principales: Joshi, Suchitra, Roden, William H., Kapur, Jaideep, Jansen, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187710/
https://www.ncbi.nlm.nih.gov/pubmed/32243088
http://dx.doi.org/10.1002/acn3.51023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187710/
https://www.ncbi.nlm.nih.gov/pubmed/32243088
http://dx.doi.org/10.1002/acn3.51023

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