Cargando…

Reduced neurosteroid potentiation of GABA(A) receptors in epilepsy and depolarized hippocampal neurons

OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ‐aminobutyric acid type‐A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is altered. We tested whether similar changes occur in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joshi, Suchitra, Roden, William H., Kapur, Jaideep, Jansen, Laura A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187710/ https://www.ncbi.nlm.nih.gov/pubmed/32243088 http://dx.doi.org/10.1002/acn3.51023

Ejemplares similares

Neurosteroids and GABA-A Receptor Function
por: Wang, Mingde
Publicado: (2011)

Probing GABA(A) receptors with inhibitory neurosteroids
por: Seljeset, Sandra, et al.
Publicado: (2018)

The Depolarizing Action of GABA in Cultured Hippocampal Neurons Is Not Due to the Absence of Ketone Bodies
por: Waddell, Jaylyn, et al.
Publicado: (2011)

The Mechanism of Enantioselective Neurosteroid Actions on GABA(A) Receptors
por: Tateiwa, Hiroki, et al.
Publicado: (2023)

Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress
por: Gunn, Benjamin G., et al.
Publicado: (2011)

Multiple functional neurosteroid binding sites on GABA(A) receptors
por: Chen, Zi-Wei, et al.
Publicado: (2019)

Structural basis of neurosteroid anesthetic action on GABA(A) receptors
por: Chen, Qiang, et al.
Publicado: (2018)

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
por: Zorumski, Charles F., et al.
Publicado: (2019)

Structural insights into opposing actions of neurosteroids on GABA(A) receptors
por: Legesse, Dagimhiwat H., et al.
Publicado: (2023)

Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization
por: Sugasawa, Yusuke, et al.
Publicado: (2020)

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA(A) receptors
por: Adams, Joanna M., et al.
Publicado: (2015)

Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABA(A) Receptors in Dentate Granule Neurons
por: Lu, Xinguo, et al.
Publicado: (2020)

Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?
por: Wetten, Aaron, et al.
Publicado: (2022)

Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
por: Hulin, Mary W., et al.
Publicado: (2011)

Contribution of Resting Conductance, GABA(A)-Receptor Mediated Miniature Synaptic Currents and Neurosteroid to Chloride Homeostasis in Central Neurons
por: Yelhekar, Tushar D., et al.
Publicado: (2017)

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons
por: Brown, Adam R., et al.
Publicado: (2016)

GABA(A) receptor-acting neurosteroids: A role in the development and regulation of the stress response
por: Gunn, Benjamin G., et al.
Publicado: (2015)

Limbic progesterone receptors regulate spatial memory
por: Joshi, Suchitra, et al.
Publicado: (2023)

Progesterone receptor activation regulates seizure susceptibility
por: Shiono, Shinnosuke, et al.
Publicado: (2019)

Neurosteroid Modulation of GABA(A) Receptor Function by Independent Action at Multiple Specific Binding Sites
por: Wang, Lei, et al.
Publicado: (2022)

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit
por: Salmon, Christopher K., et al.
Publicado: (2020)

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy
por: Eichler, Sabrina A, et al.
Publicado: (2008)

Extra-Synaptic GABA(A) Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABA(A) Modulating Steroid Antagonist
por: Bengtsson, Sara K. S., et al.
Publicado: (2023)

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons
por: Tozzi, Alessandro, et al.
Publicado: (2019)

Characterization of Inhibitory GABA-A Receptor Activation during Spreading Depolarization in Brain Slice
por: Aiba, Isamu, et al.
Publicado: (2014)

Role of Anticonvulsant and Antiepileptogenic Neurosteroids in the Pathophysiology and Treatment of Epilepsy
por: Reddy, Doodipala Samba
Publicado: (2011)

Protocadherin 19 Clustering Epilepsy and Neurosteroids: Opportunities for Intervention
por: de Nys, Rebekah, et al.
Publicado: (2021)

GABA Receptors Can Depolarize the Neuronal Membrane Potential via Quantum Tunneling of Chloride Ions: A Quantum Mathematical Study
por: Nawafleh, Sager, et al.
Publicado: (2022)

Commentary: GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo
por: Ben-Ari, Yehezkel
Publicado: (2015)

Commentary: GABA Depolarizes Immature Neurons and Inhibits Network Activity in the Neonatal Neocortex In vivo
por: Zilberter, Yuri
Publicado: (2015)

Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABA(A) Receptor Inhibition Require the δ-Subunit
por: Littlejohn, Erica L., et al.
Publicado: (2021)

Difluoroboron β-diketonate polylactic acid oxygen nanosensors for intracellular neuronal imaging
por: Zhuang, Meng, et al.
Publicado: (2021)

Neurosteroid effects in the central nervous system : the role of the GABA-A receptor
Publicado: (2004)

Examining Neurosteroid-Analogue Therapy in the Preterm Neonate For Promoting Hippocampal Neurodevelopment
por: Shaw, Julia C., et al.
Publicado: (2022)

Coincident glutamatergic depolarizations enhance GABA(A) receptor-dependent Cl(-) influx in mature and suppress Cl(-) efflux in immature neurons
por: Lombardi, Aniello, et al.
Publicado: (2021)

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABA(A) receptor mediated currents
por: Lee, Henry H.C., et al.
Publicado: (2011)

GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study
por: Johansson, Maja, et al.
Publicado: (2018)

Depolarization of Hippocampal Neurons Induces Formation of Nonsynaptic NMDA Receptor Islands Resembling Nascent Postsynaptic Densities123
por: Tao-Cheng, Jung-Hwa, et al.
Publicado: (2015)

GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy
por: Johansson, Maja, et al.
Publicado: (2015)

Prolactin Reduces Hippocampal Parvalbumin and GABA(A) Receptor Expression in Female Mice
por: Mellado, Susana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m4i2lsumpsqtk3unfbnt2ggnp9