The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice

The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear export receptor Crm1. NUP fusion leukemias are char...

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Detalles Bibliográficos
Autores principales: Lavau, Catherine P., Aumann, Waitman K., Sze, Sei-Gyung K., Gupta, Veerain, Ripple, Katelyn, Port, Sarah A., Kehlenbach, Ralph H., Wechsler, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188244/
https://www.ncbi.nlm.nih.gov/pubmed/32343715
http://dx.doi.org/10.1371/journal.pone.0232036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188244/
https://www.ncbi.nlm.nih.gov/pubmed/32343715
http://dx.doi.org/10.1371/journal.pone.0232036

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