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S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disorder which is mostly sporadic but familial-linked PD (FPD) cases have also been found. The first reported gene mutation that linked to PD is α-synuclein (α-syn). Studies have shown that mutations, increased expression or abnormal processing...

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Detalles Bibliográficos
Autores principales: Wu, Weiwei, Sung, Chun Chau, Yu, Peichun, Li, Jiahua, Chung, Kenny K. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188290/
https://www.ncbi.nlm.nih.gov/pubmed/32343709
http://dx.doi.org/10.1371/journal.pone.0232019