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Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data

[Image: see text] Amyloid fibril formation is a hallmark of neurodegenerative disease caused by protein aggregation. Oligomeric protein states that arise during the process of fibril formation often coexist with mature fibrils and are known to cause cell death in disease model systems. Progress in t...

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Detalles Bibliográficos
Autores principales: Jensen, Kristine Steen, Linse, Sara, Nilsson, Mathias, Akke, Mikael, Malmendal, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188332/
https://www.ncbi.nlm.nih.gov/pubmed/31702142
http://dx.doi.org/10.1021/jacs.9b07952