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DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in gene expression. The histone methyltransferase DOT1L, which mono-, di- and trimethylates H3K79 using S-adenosyl-L-methionine as a co-factor, is involved in cell development, cell cycle progression, and DNA d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188393/ https://www.ncbi.nlm.nih.gov/pubmed/31790636 http://dx.doi.org/10.1080/15592294.2019.1699991 |