Cargando…

A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development

Glycosylation is a common post-translational modification and critical quality attribute that can modulate the efficacy of therapeutic proteins. In the production of monoclonal antibodies (mAbs), quantifying the glycoform profile is a vital characterization step. Traditional glycan analysis is time...

Descripción completa

Detalles Bibliográficos
Autores principales: Segu, Zaneer, Stone, Todd, Berdugo, Claudia, Roberts, Anthony, Doud, Emma, Li, Yunsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188402/
https://www.ncbi.nlm.nih.gov/pubmed/32249667
http://dx.doi.org/10.1080/19420862.2020.1750794