Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats

Sedatives are suspected contributors to neurologic dysfunction in PICU patients, to whom they are administered during sensitive neurodevelopment. Relevant preclinical modeling has largely used comparatively brief anesthesia in infant age-approximate animals, with insufficient study of repetitive com...

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Detalles Bibliográficos
Autores principales: Iqbal O’Meara, Alia Marie, Miller Ferguson, Nikki, Zven, Sidney E., Karam, Oliver L., Meyer, Logan C., Bigbee, John W., Sato-Bigbee, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Original Basic Science Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188419/
https://www.ncbi.nlm.nih.gov/pubmed/32426747
http://dx.doi.org/10.1097/CCE.0000000000000105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188419/
https://www.ncbi.nlm.nih.gov/pubmed/32426747
http://dx.doi.org/10.1097/CCE.0000000000000105

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