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Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
Sedatives are suspected contributors to neurologic dysfunction in PICU patients, to whom they are administered during sensitive neurodevelopment. Relevant preclinical modeling has largely used comparatively brief anesthesia in infant age-approximate animals, with insufficient study of repetitive com...
Autores principales: | Iqbal O’Meara, Alia Marie, Miller Ferguson, Nikki, Zven, Sidney E., Karam, Oliver L., Meyer, Logan C., Bigbee, John W., Sato-Bigbee, Carmen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188419/ https://www.ncbi.nlm.nih.gov/pubmed/32426747 http://dx.doi.org/10.1097/CCE.0000000000000105 |
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