Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs, UGTs impair the biological activity and enhance the water solubility of these agents, driving their elimination. Multiple c...

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Detalles Bibliográficos
Autores principales: Allain, Eric P., Rouleau, Michèle, Lévesque, Eric, Guillemette, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188667/
https://www.ncbi.nlm.nih.gov/pubmed/32047295
http://dx.doi.org/10.1038/s41416-019-0722-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188667/
https://www.ncbi.nlm.nih.gov/pubmed/32047295
http://dx.doi.org/10.1038/s41416-019-0722-0

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