Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells

BACKGROUND: Akt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition. However, cancer cells can utilise alternative nutrients to glucose for energy such as lactate, which is often elevated in tumours...

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Detalles Bibliográficos
Autores principales: Barnes, Emily M. E., Xu, Yitao, Benito, Adrian, Herendi, Lili, Siskos, Alexandros P., Aboagye, Eric O., Nijhuis, Anke, Keun, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188671/
https://www.ncbi.nlm.nih.gov/pubmed/32152504
http://dx.doi.org/10.1038/s41416-020-0777-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188671/
https://www.ncbi.nlm.nih.gov/pubmed/32152504
http://dx.doi.org/10.1038/s41416-020-0777-y

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