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Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells
BACKGROUND: Akt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition. However, cancer cells can utilise alternative nutrients to glucose for energy such as lactate, which is often elevated in tumours...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188671/ https://www.ncbi.nlm.nih.gov/pubmed/32152504 http://dx.doi.org/10.1038/s41416-020-0777-y |