Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design

Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations...

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Detalles Bibliográficos
Autores principales: Bheemanapally, Khaggeswar, Ibrahim, Mostafa M. H., Briski, Karen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188808/
https://www.ncbi.nlm.nih.gov/pubmed/32346010
http://dx.doi.org/10.1038/s41598-020-64099-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188808/
https://www.ncbi.nlm.nih.gov/pubmed/32346010
http://dx.doi.org/10.1038/s41598-020-64099-w

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