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Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glutamine-FMOC Ad-Hoc Derivative by Central Composite Design

Glutamine (Gln) is converted to excitatory (glutamate, aspartate) and inhibitory (γ-amino butyric acid) amino acid neurotransmitters in brain, and is a source of energy during glucose deprivation. Current research utilized an Analytical Quality by Design approach to optimize levels and combinations...

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Detalles Bibliográficos
Autores principales:	Bheemanapally, Khaggeswar, Ibrahim, Mostafa M. H., Briski, Karen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188808/ https://www.ncbi.nlm.nih.gov/pubmed/32346010 http://dx.doi.org/10.1038/s41598-020-64099-w

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