Cargando…

The synthetic LPS binding peptide 19-2.5 interferes with clotting and prevents degradation of high molecular weight kininogen in plasma

Sepsis and septic shock are life-threatening conditions and remain an important medical problem, emphasizing the need to identify novel therapeutic approaches. Coagulation dysfunction, hypotension, disturbed microcirculation and multiorgan failure occur frequently. These severe conditions result fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Köhler, Juliane, Ehler, Johannes, Kreikemeyer, Bernd, Bajorath, Rika, Schürholz, Tobias, Oehmcke-Hecht, Sonja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188841/ https://www.ncbi.nlm.nih.gov/pubmed/32346013 http://dx.doi.org/10.1038/s41598-020-64155-5

Ejemplares similares

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis
por: Köhler, Juliane, et al.
Publicado: (2020)

Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system
por: Isenring, Julia, et al.
Publicado: (2017)

Streptococcus gallolyticus abrogates anti-carcinogenic properties of tannic acid on low-passage colorectal carcinomas
por: Oehmcke-Hecht, Sonja, et al.
Publicado: (2020)

Interaction of the Human Contact System with Pathogens—An Update
por: Oehmcke-Hecht, Sonja, et al.
Publicado: (2018)

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms
por: Singh, Pradeep K., et al.
Publicado: (2022)

High intravascular tissue factor—but not extracellular microvesicles—in septic patients is associated with a high SAPS II score
por: Trepesch, Carolin, et al.
Publicado: (2016)

Port d’Entrée for Respiratory Infections – Does the Influenza A Virus Pave the Way for Bacteria?
por: Siemens, Nikolai, et al.
Publicado: (2017)

Deletion of the L-Lactate Dehydrogenase Gene ldh in Streptococcus pyogenes Leads to a Loss of SpeB Activity and a Hypovirulent Phenotype
por: Oehmcke-Hecht, Sonja, et al.
Publicado: (2017)

Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity
Publicado: (1988)

The Effect of Early Application of Synthetic Peptides 19-2.5 and 19-4LF to Improve Survival and Neurological Outcome in a Mouse Model of Cardiac Arrest and Resuscitation
por: Bajorat, Rika, et al.
Publicado: (2023)

Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type-1 diabetes
por: Merchant, Michael L., et al.
Publicado: (2013)

Relationship between structure and correcting activity of bovine high molecular weight kininogen upon the clotting time of fitzgerald-trait plasma
por: Scicli, AG, et al.
Publicado: (1979)

Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors
por: Oehmcke-Hecht, Sonja, et al.
Publicado: (2022)

The complex role of kininogens in hereditary angioedema
por: Kaplan, Allen P., et al.
Publicado: (2022)

A Novel Role for Pro-Coagulant Microvesicles in the Early Host Defense against Streptococcus pyogenes
por: Oehmcke, Sonja, et al.
Publicado: (2013)

Characterization of human high molecular weight kininogen. Procoagulant activity associated with the light chain of kinin-free high molecular weight kininogen
Publicado: (1978)

Inhibition of cell adhesion by high molecular weight kininogen
Publicado: (1992)

An essential role of high-molecular-weight kininogen in endotoxemia
por: Yang, Aizhen, et al.
Publicado: (2017)

Welche Biomarker zu Diagnosestellung und Steuerung der antiinfektiven Therapie bei Sepsis?
por: Ehler, Johannes, et al.
Publicado: (2021)

Bradykinin Release Avoids High Molecular Weight Kininogen Endocytosis
por: Damasceno, Igor Z., et al.
Publicado: (2015)

The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
por: Wang, Bo, et al.
Publicado: (2018)

Correction: An essential role of high-molecular-weight kininogen in endotoxemia
por: Yang, Aizhen, et al.
Publicado: (2019)

High Molecular Weight Kininogen: A Review of the Structural Literature
por: Ponczek, Michał B.
Publicado: (2021)

The Regulatory Small RNA MarS Supports Virulence of Streptococcus pyogenes
por: Pappesch, Roberto, et al.
Publicado: (2017)

Effects of clot contraction on clot degradation: A mathematical and experimental approach
por: Risman, Rebecca A., et al.
Publicado: (2022)

The contact system proteases play disparate roles in streptococcal sepsis
por: Köhler, Juliane, et al.
Publicado: (2020)

Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
por: Bagnaresi, Piero, et al.
Publicado: (2012)

Kininogen Cleavage Assay: Diagnostic Assistance for Kinin-Mediated Angioedema Conditions
por: Baroso, Rémi, et al.
Publicado: (2016)

Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells
por: Xu, Jinfang, et al.
Publicado: (2018)

The Synthetic Antimicrobial Peptide 19-2.5 Interacts With Heparanase and Heparan Sulfate in Murine Sepsis In Vivo and in Human Sepsis Ex Vivo
por: Martin, L, et al.
Publicado: (2015)

High molecular weight kininogen inhibits fibrinogen binding to cytoadhesins of neutrophils and platelets
Publicado: (1989)

Kininogen Level in the Cerebrospinal Fluid May Be a Potential Biomarker for Predicting Epileptogenesis
por: Zou, Jing, et al.
Publicado: (2019)

Novel synthetic clot analogs for in-vitro stroke modelling
por: Guerreiro, Helena, et al.
Publicado: (2022)

Limitations of using synthetic blood clots for measuring in vitro clot capture efficiency of inferior vena cava filters
por: Robinson, Ronald A, et al.
Publicado: (2013)

Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen
por: Sonesson, Andreas, et al.
Publicado: (2011)

Kininogen–Nitric Oxide Signaling at Nearby Nonexcited Acupoints after Long-Term Stimulation
por: Wang, Ting, et al.
Publicado: (2021)

A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat
por: Keith, James C, et al.
Publicado: (2005)

Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses
por: Yang, Mingjia, et al.
Publicado: (2019)

The Role of Copper (II) on Kininogen Binding to Tropomyosin in the Presence of a Histidine–Proline-Rich Peptide
por: Santoro, Anna Maria, et al.
Publicado: (2020)

To Clot or Not to Clot: Is That the Question?
por: Favaloro, Emmanuel J.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t8f76c637pu3uif738kan4f31p