Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

Small synthetic molecules mimicking the three-dimensional structure of α-helices may find applications as inhibitors of therapeutically relevant protein-protein and protein-nucleic acid interactions. However, the design and use of multi-facial helix mimetics remains in its infancy. Here we describe...

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Detalles Bibliográficos
Autores principales: Medina-Trillo, Cristina, Sedgwick, Daniel M., Herrera, Lidia, Beltrán, Manuela, Moreno, Ángela, Barrio, Pablo, Bedoya, Luis. M., Alcamí, José, Fustero, Santos, Gallego, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188855/
https://www.ncbi.nlm.nih.gov/pubmed/32346097
http://dx.doi.org/10.1038/s41598-020-64120-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188855/
https://www.ncbi.nlm.nih.gov/pubmed/32346097
http://dx.doi.org/10.1038/s41598-020-64120-2

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