A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling

Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease; but their exact roles in this disease and ren...

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Detalles Bibliográficos
Autores principales: He, Xuemin, Cheng, Rui, Huang, Chao, Takahashi, Yusuke, Yang, Yanhui, Benyajati, Siribhinya, Chen, Yanming, Zhang, Xin A., Ma, Jian-xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188863/
https://www.ncbi.nlm.nih.gov/pubmed/32345960
http://dx.doi.org/10.1038/s41392-020-0142-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188863/
https://www.ncbi.nlm.nih.gov/pubmed/32345960
http://dx.doi.org/10.1038/s41392-020-0142-x

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