Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas

Papillary thyroid cancer (PTC) is the most common type of endocrine malignancy. By RNA-seq analysis, we identify a RET rearrangement in the tumour material of a patient who does not harbour any known RAS or BRAF mutations. This new gene fusion involves exons 1–4 from the 5′ end of the Trk fused Gene...

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Detalles Bibliográficos
Autores principales: Krishnan, Aswini, Berthelet, Jean, Renaud, Emilie, Rosigkeit, Sebastian, Distler, Ute, Stawiski, Eric, Wang, Jing, Modrusan, Zora, Fiedler, Marc, Bienz, Mariann, Tenzer, Stefan, Schad, Arno, Roth, Wilfried, Thiede, Bernd, Seshagiri, Somasekar, Musholt, Thomas J., Rajalingam, Krishnaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188865/
https://www.ncbi.nlm.nih.gov/pubmed/32345963
http://dx.doi.org/10.1038/s41467-020-15955-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188865/
https://www.ncbi.nlm.nih.gov/pubmed/32345963
http://dx.doi.org/10.1038/s41467-020-15955-w

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