Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited. To identify causal CHD genes that are associated with specific molecular functions, the study used prior knowledge to filter de novo variants from 2...

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Detalles Bibliográficos
Autores principales: Edwards, Jonathan J., Rouillard, Andrew D., Fernandez, Nicolas F., Wang, Zichen, Lachmann, Alexander, Shankaran, Sunita S., Bisgrove, Brent W., Demarest, Bradley, Turan, Nahid, Srivastava, Deepak, Bernstein, Daniel, Deanfield, John, Giardini, Alessandro, Porter, George, Kim, Richard, Roberts, Amy E., Newburger, Jane W., Goldmuntz, Elizabeth, Brueckner, Martina, Lifton, Richard P., Seidman, Christine E., Chung, Wendy K., Tristani-Firouzi, Martin, Yost, H. Joseph, Ma’ayan, Avi, Gelb, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188873/
https://www.ncbi.nlm.nih.gov/pubmed/32368696
http://dx.doi.org/10.1016/j.jacbts.2020.01.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188873/
https://www.ncbi.nlm.nih.gov/pubmed/32368696
http://dx.doi.org/10.1016/j.jacbts.2020.01.012

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