Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B

b-AP15 is a deubiquitinase (DUB) inhibitor of 19S proteasomes, which in turn targets ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14). Nuclear factor kappa B (NF-κB) is closely linked to cellular response in macrophages when the organism is in the state of microbi...

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Detalles Bibliográficos
Autores principales: Zhang, Fangcheng, Xu, Ruqin, Chai, Renjie, Xu, Qiong, Liu, Mingke, Chen, Xuke, Chen, Xiaohua, Kong, Tianyu, Zhang, Chongyu, Liu, Shi-Ming, Zhang, Zhenhui, Liu, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188916/
https://www.ncbi.nlm.nih.gov/pubmed/32391376
http://dx.doi.org/10.3389/fmolb.2020.00049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188916/
https://www.ncbi.nlm.nih.gov/pubmed/32391376
http://dx.doi.org/10.3389/fmolb.2020.00049

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