Cargando…

Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B

b-AP15 is a deubiquitinase (DUB) inhibitor of 19S proteasomes, which in turn targets ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14). Nuclear factor kappa B (NF-κB) is closely linked to cellular response in macrophages when the organism is in the state of microbi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Fangcheng, Xu, Ruqin, Chai, Renjie, Xu, Qiong, Liu, Mingke, Chen, Xuke, Chen, Xiaohua, Kong, Tianyu, Zhang, Chongyu, Liu, Shi-Ming, Zhang, Zhenhui, Liu, Ningning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188916/ https://www.ncbi.nlm.nih.gov/pubmed/32391376 http://dx.doi.org/10.3389/fmolb.2020.00049

Ejemplares similares

Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation
por: Zhang, Fangcheng, et al.
Publicado: (2020)

Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization
por: Xu, Ruqin, et al.
Publicado: (2019)

Ubiquitin‐specific protease 2 regulates Ang Ⅱ–induced cardiac fibroblasts activation by up‐regulating cyclin D1 and stabilizing β‐catenin in vitro
por: Xu, Qiong, et al.
Publicado: (2020)

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers
por: Cai, Jianyu, et al.
Publicado: (2017)

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment
por: Zhang, Xiaonan, et al.
Publicado: (2019)

Allium macrostemon Saponin Inhibits Activation of Platelet via the CD40 Signaling Pathway
por: Ling, Sisi, et al.
Publicado: (2021)

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
por: Mofers, Arjan, et al.
Publicado: (2019)

Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
por: Jiang, Liling, et al.
Publicado: (2019)

Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro
por: Li, Yuling, et al.
Publicado: (2022)

Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer
por: Xia, Xiaohong, et al.
Publicado: (2018)

The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells
por: Schmidt, Moritz, et al.
Publicado: (2019)

LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
por: Liu, HaiDan, et al.
Publicado: (2009)

Deubiquitinases in cancer
por: Wei, Rongbin, et al.
Publicado: (2015)

Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma
por: Qiu, Shi, et al.
Publicado: (2022)

Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation
por: Subedi, Lalita, et al.
Publicado: (2019)

An Update on the Multifaceted Role of NF-kappaB in Endometriosis
por: Liu, Yuanmeng, et al.
Publicado: (2022)

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5
por: Oh, You-Take, et al.
Publicado: (2017)

JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
por: Park, Hye Ji, et al.
Publicado: (2008)

Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations
por: Zhang, Zhifeng, et al.
Publicado: (2016)

Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB Pathway in RAW 264.7 cells
por: Yuan, Fang, et al.
Publicado: (2013)

Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds
por: Liu, Ningning, et al.
Publicado: (2015)

A Neonatal Mouse Model for Pressure Overload: Myocardial Response Corresponds to Severity
por: Gu, Jielei, et al.
Publicado: (2021)

Deubiquitination of CD36 by UCHL1 promotes foam cell formation
por: Xia, Xiaohong, et al.
Publicado: (2020)

Gypenoside-14 Reduces Depression via Downregulation of the Nuclear Factor Kappa B (NF-kB) Signaling Pathway on the Lipopolysaccharide (LPS)-Induced Depression Model
por: Jiang, Yaqun, et al.
Publicado: (2023)

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation
por: Kim, Jung-Hyun, et al.
Publicado: (2014)

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
por: Shin, Donghyuk, et al.
Publicado: (2020)

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer
por: Fukui, Shiho, et al.
Publicado: (2019)

Electroacupuncture Pretreatment Alleviates LPS-Induced Acute Respiratory Distress Syndrome via Regulating the PPAR Gamma/NF-Kappa B Signaling Pathway
por: Feng, Di, et al.
Publicado: (2020)

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation
Publicado: (1994)

AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model.
por: Suzukawa, Kazumi, et al.
Publicado: (2002)

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD
por: Komatsu, Kensei, et al.
Publicado: (2013)

The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
por: Lu, Shi-Yu, et al.
Publicado: (2017)

Higgs $\kappa_{c}$ vs $\kappa_{b}$ constraint summary plot
por: The ATLAS collaboration
Publicado: (2022)

GLP-2 Attenuates LPS-Induced Inflammation in BV-2 Cells by Inhibiting ERK1/2, JNK1/2 and NF-κB Signaling Pathways
por: Li, Nan, et al.
Publicado: (2016)

Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis.
por: Jue, D. M., et al.
Publicado: (1999)

Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB/AP-1 pathway and TLR4 expression
por: Li, Xiaolian, et al.
Publicado: (2022)

Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B
por: Wang, Jianjiang, et al.
Publicado: (2021)

Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCε and JAK2 in RAW macrophages
por: Jones, Edward, et al.
Publicado: (2007)

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
por: Xiao, Zhongxiang, et al.
Publicado: (2019)

NF-kappaB in Lung Tumorigenesis
por: Cai, Zhenjian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_64ld8qvbs768ktltn86ujp6nvn