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The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin
Microglia, the innate immune cells of the central nervous system (CNS) survey their surroundings with their cytoplasmic processes, phagocytose debris and rapidly respond to injury. These functions are affected by the presence of beta-Amyloid (Aβ) deposits, hallmark lesions of Alzheimer’s disease (AD...
Autores principales: | Drost, Natalia, Houtman, Judith, Cseresnyés, Zoltán, Niesner, Raluca, Rinnenthal, Jan-Leo, Miller, Kelly R., Prokop, Stefan, Heppner, Frank L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189379/ https://www.ncbi.nlm.nih.gov/pubmed/32346002 http://dx.doi.org/10.1038/s41598-020-63989-3 |
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