Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4...

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Detalles Bibliográficos
Autores principales: Yu, Yi, Leete, Thomas C., Born, David A., Young, Lauren, Barrera, Luis A., Lee, Seung-Joo, Rees, Holly A., Ciaramella, Giuseppe, Gaudelli, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189382/
https://www.ncbi.nlm.nih.gov/pubmed/32345976
http://dx.doi.org/10.1038/s41467-020-15887-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189382/
https://www.ncbi.nlm.nih.gov/pubmed/32345976
http://dx.doi.org/10.1038/s41467-020-15887-5

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