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Dynamics of a Key Conformational Transition in the Mechanism of Peroxiredoxin Sulfinylation

[Image: see text] Peroxiredoxins from the Prx1 subfamily (Prx) are moonlighting peroxidases that operate in peroxide signaling and are regulated by sulfinylation. Prxs offer a major model of protein–thiol oxidative modification. They react with H(2)O(2) to form a sulfenic acid intermediate that eith...

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Detalles Bibliográficos
Autores principales: Kriznik, Alexandre, Libiad, Marouane, Le Cordier, Hélène, Boukhenouna, Samia, Toledano, Michel B., Rahuel-Clermont, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189429/
https://www.ncbi.nlm.nih.gov/pubmed/32363077
http://dx.doi.org/10.1021/acscatal.9b04471