Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency

BACKGROUND: Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase small subunit (p53R2) is associated with tissue specific mitochondrial DNA (mtDNA) depletion. To understand the mechanisms of the tissue specific mtDNA depletion we systematically studied key enzymes in dTMP...

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Detalles Bibliográficos
Autores principales: Wang, Liya, Sun, Ren, Eriksson, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189545/
https://www.ncbi.nlm.nih.gov/pubmed/32345222
http://dx.doi.org/10.1186/s12860-020-00272-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189545/
https://www.ncbi.nlm.nih.gov/pubmed/32345222
http://dx.doi.org/10.1186/s12860-020-00272-3

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