Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

Amyloid-β (Aβ) associates with extracellular vesicles termed exosomes. It is not clear whether and how exosomes modulate Aβ neurotoxicity in Alzheimer’s disease (AD). We show here that brain tissue and serum from the transgenic mouse model of familial AD (5xFAD) and serum from AD patients contains c...

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Detalles Bibliográficos
Autores principales: Elsherbini, Ahmed, Kirov, Alexander S., Dinkins, Michael B., Wang, Guanghu, Qin, Haiyan, Zhu, Zhihui, Tripathi, Priyanka, Crivelli, Simone M., Bieberich, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189561/
https://www.ncbi.nlm.nih.gov/pubmed/32345374
http://dx.doi.org/10.1186/s40478-020-00931-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189561/
https://www.ncbi.nlm.nih.gov/pubmed/32345374
http://dx.doi.org/10.1186/s40478-020-00931-8

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