Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer models. However, translation of senolytic therapies...

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Detalles Bibliográficos
Autores principales: González‐Gualda, Estela, Pàez‐Ribes, Marta, Lozano‐Torres, Beatriz, Macias, David, Wilson, Joseph R., González‐López, Cristina, Ou, Hui‐Ling, Mirón‐Barroso, Sofía, Zhang, Zhenguang, Lérida‐Viso, Araceli, Blandez, Juan F., Bernardos, Andrea, Sancenón, Félix, Rovira, Miguel, Fruk, Ljiljana, Martins, Carla P., Serrano, Manuel, Doherty, Gary J., Martínez‐Máñez, Ramón, Muñoz‐Espín, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189993/
https://www.ncbi.nlm.nih.gov/pubmed/32233024
http://dx.doi.org/10.1111/acel.13142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189993/
https://www.ncbi.nlm.nih.gov/pubmed/32233024
http://dx.doi.org/10.1111/acel.13142

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