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Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions

The influenza virus hemagglutinin (HA) fusion protein has long been viewed as a “spring-loaded” fusion machine whereby activation at low pH initiates a rapid and irreversible cascade of conformational changes that drives the membrane fusion reaction. This mechanism has shaped our understanding of ho...

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Detalles Bibliográficos
Autores principales: Benhaim, M. A., Mangala Prasad, V., Garcia, N. K., Guttman, M., Lee, K. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190341/
https://www.ncbi.nlm.nih.gov/pubmed/32494683
http://dx.doi.org/10.1126/sciadv.aaz8822