Cargando…
Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions
The influenza virus hemagglutinin (HA) fusion protein has long been viewed as a “spring-loaded” fusion machine whereby activation at low pH initiates a rapid and irreversible cascade of conformational changes that drives the membrane fusion reaction. This mechanism has shaped our understanding of ho...
Autores principales: | Benhaim, M. A., Mangala Prasad, V., Garcia, N. K., Guttman, M., Lee, K. K. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190341/ https://www.ncbi.nlm.nih.gov/pubmed/32494683 http://dx.doi.org/10.1126/sciadv.aaz8822 |
Ejemplares similares
-
Structural dynamics reveal subtype-specific activation and inhibition of influenza virus hemagglutinin
por: Garcia, Natalie K., et al.
Publicado: (2023) -
Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
por: Mangala Prasad, Vidya, et al.
Publicado: (2022) -
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates
por: Ivanovic, Tijana, et al.
Publicado: (2013) -
New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes
por: Benhaim, Mark A., et al.
Publicado: (2020) -
Structural intermediates in the low pH-induced transition of influenza hemagglutinin
por: Gao, Jingjing, et al.
Publicado: (2020)