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Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation
Chronic hepatitis B virus (HBV) infection results in 887,000 deaths annually. The central challenge in curing HBV is eradication of the stable covalently closed circular DNA (cccDNA) form of the viral genome, which is formed by the repair of lesion-bearing HBV relaxed circular DNA (rcDNA) delivered...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190442/ https://www.ncbi.nlm.nih.gov/pubmed/32152586 http://dx.doi.org/10.1038/s41564-020-0678-0 |