Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

Cognitive impairment is a well-known complication of diabetes mellitus (DM). Microvascular compromise was described one DM complication. Recently we showed blood brain barrier (BBB) permeability and memory loss are associated with diminution of tight junctions (TJ) in brain endothelium and pericyte...

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Detalles Bibliográficos
Autores principales: Rom, Slava, Heldt, Nathan A., Gajghate, Sachin, Seliga, Alecia, Reichenbach, Nancy L., Persidsky, Yuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190636/
https://www.ncbi.nlm.nih.gov/pubmed/32350344
http://dx.doi.org/10.1038/s41598-020-64349-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190636/
https://www.ncbi.nlm.nih.gov/pubmed/32350344
http://dx.doi.org/10.1038/s41598-020-64349-x

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