Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

Astroviruses are a global cause of pediatric diarrhea, but they are largely understudied, and it is unclear how and where they replicate in the gut. Using an in vivo model, here we report that murine astrovirus preferentially infects actively secreting small intestinal goblet cells, specialized epit...

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Detalles Bibliográficos
Autores principales: Cortez, Valerie, Boyd, David F., Crawford, Jeremy Chase, Sharp, Bridgett, Livingston, Brandi, Rowe, Hannah M., Davis, Amy, Alsallaq, Ramzi, Robinson, Camenzind G., Vogel, Peter, Rosch, Jason W., Margolis, Elisa, Thomas, Paul G., Schultz-Cherry, Stacey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190700/
https://www.ncbi.nlm.nih.gov/pubmed/32350281
http://dx.doi.org/10.1038/s41467-020-15999-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190700/
https://www.ncbi.nlm.nih.gov/pubmed/32350281
http://dx.doi.org/10.1038/s41467-020-15999-y

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