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Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
Astroviruses are a global cause of pediatric diarrhea, but they are largely understudied, and it is unclear how and where they replicate in the gut. Using an in vivo model, here we report that murine astrovirus preferentially infects actively secreting small intestinal goblet cells, specialized epit...
Autores principales: | Cortez, Valerie, Boyd, David F., Crawford, Jeremy Chase, Sharp, Bridgett, Livingston, Brandi, Rowe, Hannah M., Davis, Amy, Alsallaq, Ramzi, Robinson, Camenzind G., Vogel, Peter, Rosch, Jason W., Margolis, Elisa, Thomas, Paul G., Schultz-Cherry, Stacey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190700/ https://www.ncbi.nlm.nih.gov/pubmed/32350281 http://dx.doi.org/10.1038/s41467-020-15999-y |
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