Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis

The monomer-to-filament transition of MAVS is essential for the RIG-I/MDA5-mediated antiviral signaling. In quiescent cells, monomeric MAVS is under strict regulation for preventing its spontaneous aggregation, which would result in dysregulated interferon (IFN-α/β) production and autoimmune disease...

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Detalles Bibliográficos
Autores principales: Shi, Yuheng, Wu, Jing, Zhong, Tiansheng, Zhu, Wenting, She, Guolan, Tang, Hao, Du, Wei, Ye, Bang-Ce, Qi, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190755/
https://www.ncbi.nlm.nih.gov/pubmed/32339989
http://dx.doi.org/10.1016/j.isci.2020.101059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190755/
https://www.ncbi.nlm.nih.gov/pubmed/32339989
http://dx.doi.org/10.1016/j.isci.2020.101059

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