Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

Mutations in myosin-VIIa (MYO7A) cause Usher syndrome type 1, characterized by combined deafness and blindness. MYO7A is proposed to function as a motor that tensions the hair cell mechanotransduction (MET) complex, but conclusive evidence is lacking. Here we report that multiple MYO7A isoforms are...

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Detalles Bibliográficos
Autores principales: Li, Sihan, Mecca, Andrew, Kim, Jeewoo, Caprara, Giusy A., Wagner, Elizabeth L., Du, Ting-Ting, Petrov, Leonid, Xu, Wenhao, Cui, Runjia, Rebustini, Ivan T., Kachar, Bechara, Peng, Anthony W., Shin, Jung-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190839/
https://www.ncbi.nlm.nih.gov/pubmed/32350269
http://dx.doi.org/10.1038/s41467-020-15936-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190839/
https://www.ncbi.nlm.nih.gov/pubmed/32350269
http://dx.doi.org/10.1038/s41467-020-15936-z

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