Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo

Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence of mammary tumours in rats. Compared to native human insulin, insulin X10 has increased binding affinity to the insulin receptor and the IGF-1...

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Detalles Bibliográficos
Autores principales: Hvid, Henning, Glendorf, Tine, Brandt, Jakob, Slaaby, Rita, Lützen, Anne, Kristensen, Kim, Hansen, Bo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190841/
https://www.ncbi.nlm.nih.gov/pubmed/32350367
http://dx.doi.org/10.1038/s41598-020-64318-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190841/
https://www.ncbi.nlm.nih.gov/pubmed/32350367
http://dx.doi.org/10.1038/s41598-020-64318-4

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