Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Glial cell line-derived neurotrophic factor (GDNF) supports function and survival of dopamine neurons that degenerate in Parkinson’s disease (PD). Ectopic delivery of GDNF in clinical trials to treat PD is safe but lacks significant therapeutic effect. In pre-clinical models, ectopic GDNF is effecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Turconi, Giorgio, Kopra, Jaakko, Võikar, Vootele, Kulesskaya, Natalia, Vilenius, Carolina, Piepponen, T. Petteri, Andressoo, Jaan-Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191127/
https://www.ncbi.nlm.nih.gov/pubmed/32368564
http://dx.doi.org/10.1016/j.omtm.2020.04.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191127/
https://www.ncbi.nlm.nih.gov/pubmed/32368564
http://dx.doi.org/10.1016/j.omtm.2020.04.003

Ejemplares similares