HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma

BACKGROUND: The selective occurrence of hepatotoxicity observed with use of pazopanib may be attributed to its high level of plasma protein binding and low hepatic extraction ratio. The primary objective was to investigate changes in free drug concentration amongst patients with varying albumin conc...

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Detalles Bibliográficos
Autores principales: Toh, Yi Long, Pang, Yi Yun, Shwe, Maung, Kanesvaran, Ravindran, Toh, Chee Keong, Chan, Alexandre, Ho, Han Kiat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191207/
https://www.ncbi.nlm.nih.gov/pubmed/32373731
http://dx.doi.org/10.1016/j.heliyon.2020.e03813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191207/
https://www.ncbi.nlm.nih.gov/pubmed/32373731
http://dx.doi.org/10.1016/j.heliyon.2020.e03813

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