Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment

SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on cleavage of the spike protein by the host cell proteases such as Cathepsin L and Cathepsin B. CTSL/B are crucial elements...

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Detalles Bibliográficos
Autores principales: Smieszek, Sandra P., Przychodzen, Bart P., Polymeropoulos, Mihael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. and International Society of Chemotherapy. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191300/
https://www.ncbi.nlm.nih.gov/pubmed/32361028
http://dx.doi.org/10.1016/j.ijantimicag.2020.106004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191300/
https://www.ncbi.nlm.nih.gov/pubmed/32361028
http://dx.doi.org/10.1016/j.ijantimicag.2020.106004

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